Differences in urinary monochlorobenzene metabolites between rats and humans
نویسندگان
چکیده
منابع مشابه
Differences in urinary monochlorobenzene metabolites between rats and humans.
The high performance liquid chromatographic method for the determination of p-chlorobenzene mercapturic acid and 4-chlorocatechol conjugates is described. For determination of urinary mercapturic acid, the benzene extract from urine was injected into a liquid chromatograph and for determination of urinary 4-chlorocatechol conjugates, hydrolysate was dissolved in methanol. The methanol solution ...
متن کاملDifferences in urinary trichloroethylene metabolites of animals.
Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats ...
متن کاملShort Communication Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
The urinary metabolites of berberine, an isoquinoline alkaloid isolated from several Chinese herbal medicines, were investigated in rats and humans. Using macroporous adsorption resin chromatography, open octadecyl silane column chromatography and preparative high-performance liquid chromatography, we isolated seven metabolites (HM1–HM7) from human urine and five metabolites (RM1–RM5) from rat ...
متن کاملIsolation and identification of urinary metabolites of berberine in rats and humans.
The urinary metabolites of berberine, an isoquinoline alkaloid isolated from several Chinese herbal medicines, were investigated in rats and humans. Using macroporous adsorption resin chromatography, open octadecyl silane column chromatography and preparative high-performance liquid chromatography, we isolated seven metabolites (HM1-HM7) from human urine and five metabolites (RM1-RM5) from rat ...
متن کاملIsolation and identification of major urinary metabolites of rifabutin in rats and humans.
The antimycobacterial drug rifabutin is extensively metabolized in humans and laboratory animals. About 40% of the dose is excreted in urine as unchanged drug, and lipophilic (extractable with 1-chlorobutane) and polar metabolites. Polar metabolites accounted for 59.1 +/- 2.5% and 88.8 +/- 4.4% of radioactivity in urine collected over 96 hr after intravenous administration of 25 and 1 mg/kg of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Archives of Occupational and Environmental Health
سال: 1983
ISSN: 0340-0131,1432-1246
DOI: 10.1007/bf00406177